Bone marrow transplant process:
Bone marrow transplant is a procedure that belongs to hematology and oncology, being performed for patients with certain cancers of the blood or bone marrow. In these cases, the recipient’s immune system is destroyed with radiation or chemotherapy prior to transplantation. Bone marrow transplant is a complex procedure with many possible implications. Many recipients of bone marrow transplants are patients with leukemia or multiple mielon which could not resist a long-term treatment or are already resistant to chemotherapy. Candidates for bone marrow transplantation include and pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia deficient stem cells. The conditions treated by bone marrow transplantation are: sickle cell anemia, myelodysplastic syndrome, neuroblastoma, lymphoma , Ewing sarcoma, desmoplastic tumors, chronic granulomatous disease, Hodgkin’s diseas.
Bone marrow options:
- Autologous grafts: autologous stem cell or bone marrow: hematopoietic stem cells require extraction from the patient, storing them in the freezer and after the high-dose chemotherapy is applied , these cells are placed in the body, taking the place and function of destroyed tissue.
- Allogenic graft: involves two people: healthy donor and patient. Donors must have a tissue type (HLA) to suit the recipient. Recipient shall require immunosuppressive medication to prevent graft-versus-host disease. Donors may be blood relatives or without family relationship having a very close HLA
Bone marrow risks :
Some of bone marrow risks include: infection, veno-occlusive disease, mucositis, graft-versus-host disease, graft-versus-tumor effect, oral carcinoma.
It is important to note that not every patient can do a bone marrow transplant. Transplantation of bone marrow or hematopoietic stem cell transplantation is an aggressive treatment method, with a mortality of 5-30%. Therefore, there are some very strict indications and only a certain category of patients can do. “The stage of disease and risk factors are key elements in the success of a transplant. The indication is strict, standardized, and is beneficial to a certain category of patients.
This blog post is an educational resource only and does not replace a medical consultation with a doctor .
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